Report from the Centre of Excellence for Sickle Cell Disease Research and Training University of Abuja (CESRTA)

Report from the Centre of Excellence for Sickle Cell Disease Research and Training University of Abuja (CESRTA)

The Centre of Excellence in Sickle Cell Disease Research and Training University of Abuja (CESRTA), was established in 2015 with the mandate to carry out basic and translational research in sickle cell disease (SCD) aimed at addressing existing knowledge gaps, finding cheaper, safer therapies as well as innovative ways of reducing the prevalence and burden of sickle cell disease in Nigeria.

CESRTA also provides the opportunity for short-, medium- and long-term training to produce the skilled workforce required for optimal care for patients with sickle cell disease and for research.

 

It has a multidisciplinary team of basic and clinical scientists, educationists and social scientists in the University working in collaboration with investigators from within and outside the country. 

 

In fulfilment of the University’s role as the University of national unity works in close collaboration with other tertiary institutions around the country and with government agencies to make it easy to implement research findings and to translate research to policy.

 

CESRTA’s activities are PI-driven with each research project leveraging on the expertise of the multidisciplinary team members at CESRTA, the network of collaborators in the Nigerian Sickle Cell Network (Sickle Cell Support Society of Nigeria) and beyond.

The scope of research is basic, clinical and translational research with emphasis on implementation research to bridge the Know-do gap in the prevention, control and management of sickle cell disease.

 

COLLABORATIONS. 

Nigeria

1.     The Federal Ministry of Health

2.     The Sickle Cell Support Society of Nigeria and its network of Clinical Centres in the six geopolitical zone

3.      H3AbioNet Node at the Centre for Genomics Research & Innovation (CGRI), National Biotechnology Development Agency (NABDA).

4.     The H3 Africa Bio-repository at the Institute of Human Virology (IHVN)

5.     The affiliate teaching hospitals- The University of Abuja Teaching Hospital and the National hospital

6.     The MDG Sickle Cell Centre New Born Screening Program at the FMC Keffi

7.     African Center of Excellence for Genomics of Infectious Diseases (ACEGID, www.acegid.org) at Redeemer’s University

8.     NIPRD

Africa

1.     The Muhimbili University of Allied and Health Sciences- Dar es Salaam, Tanzania (SPARCO, DS Africa Initiative) -infrastructure for SCD Research, uniform guidelines, skills development in health care, research and data management.

2.     The University of Ghana

3.     The University of Cape Town sickle cell disease ontology, training in big data analytics, support for data management – server at CESRTA for real time data on SCD.

International (Europe and America)

1.     Imperial College, London, mapping of survival studies in SCD

2.     Genetics of Sickle Cell Disease with University College London and Kings College. London

3.     University of Chicago

4.     NYU- implementation science research in SCD

5.     Disease Modelling Institute Seattle- Gate Foundation -SCD epidemiology.

 

6.     American Society of Haematology (Consortium on Newborn Screening in Africa for Sickle Cell Disease) CONSA to use uniform protocols for screening, management to demonstrate the efficacy of NBS to African governments. (Ghana, Tanzania, Liberia, Uganda, Kenya, Tanzania)

 

 

SPARC-NEt Sites -Institutions and Cities

SN

Hospital Name

City

SN

Hospital Name

City

1

Federal Medical Centre Keffi

Keffi

14

Ahmadu Bello University Teaching Hospital, Zaria

Zaria

2

General Hospital Nyanya

Abuja

15

Aminu Kano Teaching Hospital

Kano

3

Maitama General Hospital

Abuja

16

Barau Dikko Teaching Hospital Kaduna

Kaduna

4

National Hospital Abuja

Abuja

17

Federal Teaching Hospital Abakaliki

Abakaliki

5

Kwara State Specialist Hospital, Ilorin

Ilorin

18

Nnamdi Azikiwe University Teaching Hospital

Nnewi

6

University of Abuja Teaching Hospital, Gwagwalada

Gwagwalada

19

University of Nigeria Teaching Hospital Enugu

Enugu

7

University of Jos Teaching Hospital

Jos

20

Lagos State University Teaching Hospital

Lagos

8

Zankli Medical Centre

Abuja

21

University College Hospital, Ibadan

Ibadan

9

Benue state University Teaching Hospital Damaturu

Makurdi

22

Obafemi Awolowo University Teaching Hospital

Ife

10

University of Maiduguri Teaching Hospital

Maiduguri

23

Irrua Specialist Teaching Hospital

Benin

11

Federal Medical Centre Yola

Yola

24

Rivers State University Teaching Hospital

Port Harcourt

12

Yobe state University Teaching Hospital Damaturu

Damaturu

25

University of Uyo Specialist Hospital, Uyo

Uyo

13

Federal Medical Centre B/K

Birnin Kebbi

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Basic and Social Science Research

  1. Economic burden of sickle cell disease in Nigeria
  2. Anti-sickling activity, haematological and biochemical effects of medicinal plants from Gwagwalada Area Council and surrounding territories.
  3. Education Intervention for the Control of SCD

 

Implementation Research

1.     Penicillin prophylaxis

2.     Newborn Screening (The CONSA NBS program 6,000 babies in Abuja with IEF, and nationwide screening with POCT in SPARC-NEt sites, 10,000/yr for 5 years. Birth cohorts established for survival and microbiome studies)

3.     Hydroxyurea utilisation

 

Clinical Research

1.     Cohort studies comparative studies

2.     Invasive pneumococcal disease (IPV)

3.     Genomics of sickle cell disease (genetic modifiers, Hb cells, microbiome of SCD in birth cohort)

4.     SCD and COVID

5.     Blood transfusion in SCD

 

Data Science Research

Aimed at the optimal use of data science to improve health and research by making use of health data available both in public health and in health care facilities as well as genomic data to improve the health of individuals with SCD.

Output

The impact of our work is gaining recognition in local and international news media with increasing contribution in peer reviewed journals 27 out of which 10 were published this year with six acceptances awaiting publication.

Gaps Noted

1.     Data on number of babies born with SCD

2.     Adequate support for complex statistical and data analysis

3.     Capacity for genomics research in SCD.

4.     Challenges with follow up of babies identified in the NBS

Next Steps

1.     Use of mobile technology for data collection from the newborn screening program and the clinical centres

2.     Use of smart cards to allow people to access health care in affiliated clinical centres nationwide to improve retention in the registry

3.     Population based genetic counseling.

 

CESRTA has opportunities for Research Fellowships in SCD for Masters and PhD students

 

News Items

1.     https://www.nhlbi.nih.gov/todays-faces-sickle-cell-disease/obiageli-nnodu-md

2.     https://www.nhlbi.nih.gov/news/2019/rapid-result-test-track-transform-sickle-cell-disease-screening-millions

3.     https://qz.com/africa/1873730/new-sickle-cell-screening-for-newborns-in-africa-could-save-lives/

4.     https://www.hcplive.com/view/point-of-care-newborn-testing-pediatric-sickle-cell-care

 

5.     https://leadership.ng/sickle-cell-consa-launches-sites-to-screen-16000-babies-in-abuja-kaduna/

6.     http://www.ashnewsdaily.org/www-ashnewsdaily-org-why-i-volunteer-international-consortium-on-newborn-screening-in-africa/

NEWS FEEDS