Centre of Excellence for Sickle Cell Disease RESEARCH & Training, University of AbujA (CESRTA)
Achievements of CESRTA
Four TETFUND IBRs were awarded to CESRTA Team members to undertake the following research studies
1. Economic burden of sickle cell disease in Nigeria, PI-Nnodu.
2. Anti-sickling activity, haematological and biochemical effects of medicinal plants from rural communities in Gwagwalada, PI- Alli.
3. Metagenomics of Leg Ulcers at the University of Abuja Teaching Hospital, PI- Abubakar.
4. Education intervention for the control of sickle cell disease in Gwagwalada Area Council, PI-Odumuh
1. A seed fund has been granted to researchers at Kings College London to set up research collaboration with the Center through a pilot project to test for quantitative locus variants (disease modifying genes) in patients with sickle cell disease.
2. The Center was successful in the application for the NIH RFA for Sickle Cell Disease in Sub Saharan Africa Collaborative Consortium which will sent up the infrastructure for sickle cell disease research and training in 5 African countries, including Tanzania, Nigeria, Ghana. The grant is for four years and is meant to support future studies in SCD. Multidisciplinary teams of researchers should undertake pilot projects now in order to be competitive for subsequent research calls.
3. A revised grant proposal has been granted byDoris Duke Charitable Foundation in collaboration the University of Chicago and University of Ibadan for pilot newborn screening for SCD in Gwagwalada Area Council followed by evidence based interventions for those detected with SCD.
A number of proposals have been developed for institutional research grants.
1. A novel pilot study evaluating the point of care test for sickle haemoglobin (SickleSCANTM) conducted followed by a nationwide study of the acceptability and feasibility of the use of SickleSCANTM in screening primary at health care centres was conducted. Our findings showed that SickleSCANTM can be used to screen for SCD at primary health care levels. The manuscript has been submitted for publication.
2. Participation in the development of the first Ontology for SCD in the world and publication of the workshop proceedings.
3. Collaborations are being established with relevant institutions for skills development in data base management, bioinformatics, genomics, preventative and health care management services and for research.
1 Three members of the research team at CESRTA made oral presentations at the 6th International Symposium on Sickle Cell Disease, Labadi Beach Hotel, Accra, Ghana, 11-15th July 2016
2 A presentation was made at the ASH African Newborn Screening for Sickle Cell Disease and Early Intervention Consortium Meeting San Diego, California, 6 December 2016.
1. One member of the CESRTA Team is undergoing molecular haematology training in Brazil under the Fiocruz Foundation Scholarship program which is an initiative of the Sickle Cell Support Society of Nigeria to build capacity for SCD research in Nigeria.
2. One member of the CESRTA has submitted an application for Novartis Institute for Biomedical Research 2017 Global Health Fellowship Program. This initiative, facilitated by Professor Olufunmilayo Olopade of the University of Chicago, will allow for 10-12 weeks of focused training on therapeutic drug monitoring of hydroxyurea at the Novartis Institute of Biomedical Research in Cambridge MA, USA. This will open up collaboration for further research in SCD.
3. A post graduate diploma program in Bioinformatics is being developed with the National Biotechnology Development Agency.
4. The curriculum for a Masters in Clinical Science to be offered through one of the Departments in the College of Health Sciences is being developed.